Urolithin A is a compound your gut bacteria make from ellagitannins in pomegranate, walnuts and berries, and it is marketed as a way to help cells clear out worn-out mitochondria. Supplements skip the gut step and give you the finished molecule. The catch is that almost all the human research used one branded ingredient, Mitopure, mostly in trials its maker funded, and independent label tests have found products far off their stated dose.
So this ranking rewards what you can check: whether the product uses the trial ingredient, whether someone independent confirmed what is in it, the price per 500 mg, how much else is mixed in, and how far the marketing outruns the trials. We read the printed label on every product below and scored all eight on the same five criteria. For the background, see our urolithin A explainer.
The short version
- Best overall: Timeline Mitopure Softgels, the trial ingredient at 500 mg, NSF Certified for Sport, but about $3.30 a day.
- Best value: Codeage Liposomal Urolithin A, 500 mg and NSF/ANSI 173 listed, though its source is not Mitopure and the Amazon price may not last.
- Best lab-verified alternative: ProHealth, with a named-lab certificate showing 510 mg per serving.
- The trials are mixed. The largest trials, in older adults, middle-aged adults and elite runners, missed their main outcomes; gains showed up in some secondary lab tests.
- Mostly company-funded. 6 of the 10 oral trials we reviewed were sponsored or funded by Mitopure's maker, and the two fully independent trials missed their main outcomes.
- Label accuracy varies. An independent test found labeled urolithin A products ranging from 15.5 percent under to 28.6 percent over their claims.
- Pomegranate extract is not urolithin A. Many people make little or none from food, and a pomegranate product is not a substitute for the finished compound.
How we ranked them
Every product here sells the same molecule at a similar dose, so we scored what separates them:
- Urolithin A source and dose (30%). Full marks for Mitopure at 500 mg or more a day, the ingredient used in nearly all published trials and the only urolithin A with an FDA GRAS notice. Other urolithin A at 500 mg scores lower, because we found no GRAS notice or new dietary ingredient filing for it and it is not what the trials tested.
- Content verification (25%). Full marks for NSF Certified for Sport, then an NSF/ANSI 173 listing, both confirmed on NSF's sites on October 19, 2026; then a published certificate of analysis that names its lab; then an unnamed testing claim or nothing.
- Cost per 500 mg (20%), from Amazon prices on October 19, 2026. When the Amazon price is under half the brand's own list price, we score the list price.
- Formula focus (10%). Urolithin A alone scores highest; every added active is something the trials did not test, and a title that overstates the urolithin A dose costs a point.
- Marketing restraint (15%). Points come off (half a point per category) for claims beyond the trials, such as reversing aging or helping the heart and brain, unverifiable "#1" or comparison claims, unsupported statistics, absorption claims for delivery systems, and misstatements about trial doses.
Scores are rounded to one decimal. Chewable and powder versions of Mitopure are covered below, along with two products we do not recommend. No brand paid to be included, and none sent product.
What urolithin A trials actually show
What the trials measured. The first human trial, in older adults, found urolithin A safe at single doses up to 2,000 mg and saw changes in blood and muscle markers after four weeks. The headline trials came next. In 66 adults aged 65 to 90, 1,000 mg a day for four months did not significantly improve the main outcomes, six-minute walk distance and muscle energy production; hand and leg endurance was better than placebo at two months, but by four months the placebo group had caught up and the difference was not significant. In 88 overweight middle-aged adults, the main outcome, peak power, did not improve significantly; hamstring strength rose about 12 percent on 500 mg, a significant difference from placebo, partly because strength fell in the placebo group, and gains in walking distance and peak oxygen uptake were not significant against placebo.
Other trials. In 42 elite runners, four weeks at 1,000 mg did not significantly improve a 3,000 m time trial, though perceived effort and a muscle-damage marker were lower. In 50 middle-aged adults, four weeks shifted some immune-cell markers. Two small trials reported gains on some tests: 20 resistance-trained men improved repetitions to failure but not their one-rep maximums, and a single-blind pilot in 20 teenage soccer players met its main endurance test by a narrow margin. The two fully independent trials missed their main outcomes: 50 adults with obesity showed no significant change in blood-vessel function, and a 10-patient heart trial found no significant change in heart measures. A 2026 meta-analysis could pool only one outcome, the six-minute walk, and found no significant difference.
Who funded them. Of the 10 oral trials we reviewed, 6 were sponsored or funded by Amazentis, which makes Mitopure, and most included its employees as authors. Every outcome measured in the published trials we found is a lab or performance test; none looked at falls, frailty, infections or heart events.
Making your own. How much urolithin A your gut makes depends on your bacteria, and the estimates depend on the definition: in a sponsor-funded study, only 12 percent of adults had detectable urolithin A at the start and about 40 percent converted a glass of pomegranate juice into meaningful amounts, while other studies put the share who make none at all at 5 to 25 percent. In that study, 500 mg of urolithin A gave more than six times the exposure of the juice. In a separate trial of pomegranate extract, 6 of 20 people never produced urolithin A at all.
Regulatory status and label accuracy. Mitopure's maker filed a GRAS notice (GRN 791) for urolithin A in foods such as protein shakes and yogurt, up to 500 or 1,000 mg per serving, and FDA replied in December 2018 that it had no questions; that is not approval and does not cover health claims. We found no other urolithin A GRAS notice and no new dietary ingredient filing. In an independent 2024 test, labeled urolithin A products ranged from 15.5 percent under to 28.6 percent over their claims, and testing commissioned by Mitopure's maker reported no urolithin A in two Amazon products.
The 8 best urolithin A supplements
Tap any product to jump straight to its full review.
Timeline Mitopure Urolithin A Softgels
Best for: People who want the trial ingredient with NSF Certified for Sport
The top pick because it is the trial ingredient with the strongest verification: 2 softgels give 500 mg of Mitopure with nothing else added, and the softgels are NSF Certified for Sport and NSF/ANSI 173 listed, both confirmed on NSF's sites. The trade-offs are cost, about $3.30 a day for a dose half of what most trials used, and marketing that runs ahead of the research: "clinically proven to change how cells age", organ icons for the heart, brain and immunity, a #1 doctor-recommended survey claim, and an unsupported claim that mitochondrial function declines from age 30.
- Mitopure, the urolithin A used in nearly all published trials and the only one with an FDA GRAS notice
- NSF Certified for Sport and NSF/ANSI 173, both confirmed on NSF's sites
- 500 mg in 2 softgels with nothing else added
- More than 1,000 Amazon ratings averaging 4.5 stars
- About $3.30 a day, the most expensive single-ingredient option here
- Trials more often used 1,000 mg, which would double the cost
- Its maker funded most of the trials it cites, and the largest ones missed their main outcomes
- The listing says it is "clinically proven to change how cells age" and shows heart, brain and immunity icons
Codeage Liposomal Urolithin A
Best for: A lower price with an NSF/ANSI 173 listing
The best value: 500 mg of urolithin A in 2 capsules, with an NSF/ANSI 173 listing confirmed on NSF's site, which means the label amount is independently checked. Even at the brand's own $69.99 list price it costs less per 500 mg than Mitopure, and the Amazon price on October 19 was $23.95. It ranks second because the urolithin A source is not named and is not Mitopure, the listing is new with no ratings, and the phospholipid carrier has no evidence of better absorption.
- Listed under NSF/ANSI 173, which includes checking the label amount; we confirmed it on NSF's site
- 500 mg of urolithin A with no other actives
- Far cheaper than Mitopure, even at the brand's own $69.99 list price
- A plain listing without longevity or organ claims
- The urolithin A source is not named; it is not Mitopure, the ingredient used in the trials
- A new listing with no Amazon ratings yet
- The $23.95 Amazon price is about a third of the brand's list price and may not last
- The phospholipid carrier has not been shown to improve urolithin A absorption
ProHealth Full Spectrum Urolithin A
Best for: Buyers who want to see a named lab's test result
The best-verified non-Mitopure option after Codeage: its listing shows a certificate of analysis from a named lab, Qalitex, measuring 510 mg of urolithin A per 2-capsule serving in January 2026. It uses StanYouth urolithin A plus pomegranate and muscadine grape extracts, at about $2.44 a day. It loses points for a non-trial ingredient, no NSF listing, and a claim that about 60 percent of people lack the bacteria to make urolithin A, citing a study that measured conversion after one glass of pomegranate juice rather than missing bacteria.
- Shows a certificate of analysis from a named lab, Qalitex, measuring 510 mg of urolithin A per serving (January 2026)
- 500 mg of urolithin A per serving
- Adds 250 mg of Pomanox pomegranate extract and 100 mg of muscadine grape extract
- StanYouth urolithin A is not Mitopure, the ingredient used in the trials
- About $2.44 a day
- Says "approximately 60% of people lack the gut bacteria" to make urolithin A, citing a sponsor study that measured conversion after one glass of pomegranate juice, not missing bacteria
- We found no NSF listing for it
Toniiq Urolithin A Complex
Best for: The lowest daily cost, if an unnamed lab is acceptable
The cheapest product here at about $1.17 a day for 500 mg of urolithin A, with pomegranate extract, 100 mg of NMN and prebiotic fiber added. It ranks lower because its certificate-of-analysis image names no lab and says full results are available on request, the source is not named, and the extras were not part of the urolithin A trials. The listing also compares its "elevated" urolithin A with unnamed other brands.
- About $1.17 a day for 500 mg of urolithin A
- Also includes 500 mg pomegranate extract, 100 mg NMN and 400 mg of PHGG fiber
- Lists every amount, with no proprietary blend
- Its certificate-of-analysis image names no lab and says full results are available on request
- The urolithin A source is not named and is not Mitopure
- Three capsules a day, and the extras were not part of the urolithin A trials
- Compares its "elevated" urolithin A purity with unnamed other retail brands
PlantFusion Urolithin A 500 mg
Best for: One capsule a day
The simplest way to take 500 mg, in one capsule a day, at about $1.83. It says it publishes finished-product test results online, but neither the listing nor the brand's product page shows them or names a lab. It also says 500 mg matches the dose in most human studies, when most trials used 1,000 mg, ties urolithin A to NAD and NADH cycling, which the trials did not study, and compares itself with other labels and companies.
- One capsule a day gives 500 mg of urolithin A
- A two-month bottle at about $1.83 a day
- Says it publishes finished-product test results online
- Its test results are not shown on the listing or the brand's product page, and no lab is named
- Says 500 mg matches the dose "used in most human clinical studies"; most trials used 1,000 mg
- Ties urolithin A to "NAD and NADH cycling", which the trials did not study, and compares itself with other labels
- The urolithin A source is not named and is not Mitopure
Pure O Elements Urolithin A + NAD Complex
Best for: People who also want NAD in the same capsule
A combination of 500 mg urolithin A with 500 mg NAD, 150 mg Japanese knotweed extract (about 75 mg trans-resveratrol) and 100 mg CoQ10 for about $2.00 a day. It loses points for a title that says "Urolithin A 1000mg" when the label gives 500 mg of urolithin A, for liposomal absorption and focus claims, and for a testing claim that names no lab.
- 500 mg of urolithin A plus 500 mg NAD, 150 mg Japanese knotweed extract (about 75 mg trans-resveratrol) and 100 mg CoQ10
- About $2.00 a day for the combination
- The title says "Urolithin A 1000mg", but the label gives 500 mg of urolithin A; the 1,000 mg counts NAD too
- Claims liposomal "enhanced bioavailability" and focus benefits that no urolithin A trial has shown
- "3rd party tested" names no lab
- The urolithin A source is not named and is not Mitopure
Revive Longevity Core
Best for: People who want an all-in-one longevity stack
A six-ingredient longevity stack built around 500 mg of urolithin A with rhodiola, CoQ10, apigenin, PQQ and black pepper extract, at about $2.50 a day. Every amount is listed, but its third-party testing claim names no lab, it has only 8 ratings, it claims enhanced absorption from BioPerine, and it lists less fatigue and sharper focus among benefits felt in the first weeks, which no urolithin A trial has shown.
- 500 mg of urolithin A with 200 mg rhodiola, 100 mg CoQ10, 50 mg apigenin and 15 mg PQQ
- Every amount is listed, with no proprietary blend
- Says it is third-party tested but names no lab and shows no certificate
- Lists less fatigue and sharper focus among benefits "felt in the first weeks", which no urolithin A trial has shown
- Five other actives, so you cannot tell what any one does
- Only 8 Amazon ratings
Pure Encapsulations Renual
Best for: Pure Encapsulations fans who want Mitopure at a lower dose
The only other Mitopure product we found, from a long-established brand with a restrained listing. The problem is the dose: 2 capsules give 250 mg of urolithin A with resveratrol and CoQ10, so 500 mg takes 4 capsules and a bottle lasts 15 days, about $5.27 per 500 mg. We found no NSF listing for it.
- Uses Mitopure, the trial ingredient
- Adds 150 mg trans-resveratrol and 60 mg CoQ10
- A restrained listing from a long-established brand
- Only 250 mg of urolithin A per 2-capsule serving; 500 mg takes 4 capsules
- About $5.27 per 500 mg, the most expensive here
- We found no NSF listing for it
Timeline Mitopure Gummies. The same 500 mg of Mitopure in 2 sugar-free gummies at the same $99. Its listing says "NSF Contents Certified" and repeats the softgels' NSF Certified for Sport line, but the NSF listings we found covered the softgels and powder, not the gummies. Check price on Amazon $99.00 for 60 gummies · seen October 19, 2026
Timeline Mitopure Berry Powder. 500 mg of Mitopure per 3 g packet, NSF Certified for Sport, designed to stir into food rather than water, also $99 a month. Check price on Amazon $99.00 for 30 packets · seen October 19, 2026
Not recommended: Neurogan Urolithin Precursor Pro+ contains no urolithin A; it relies on pomegranate extract and other ingredients that only some people convert. Nutri Urolithin A Diacetate is a different compound, and we found no human trials of it.
The full lineup, side by side
Amounts come from each product's printed label; verification comes from the certifier's own listing or a certificate naming its lab. Check the source and verification columns first: independent tests have found urolithin A products well off their labels, and some with none.
| Product | Urolithin A source | UA per day (label) | Other actives | Verified by | Cost per 500 mg | Score |
|---|---|---|---|---|---|---|
| #1 Timeline Mitopure | Mitopure | 500 mg | None | NSF Certified for Sport, NSF/ANSI 173 | $3.30 | 4.1 |
| #2 Codeage | Not named | 500 mg | None | NSF/ANSI 173 | $0.80 (list $2.33) | 4.0 |
| #3 ProHealth | StanYouth | 500 mg | Pomegranate, muscadine grape | Named-lab COA (Qalitex) | $2.44 | 3.7 |
| #4 Toniiq | Not named | 500 mg | Pomegranate, NMN, PHGG fiber | Unnamed COA | $1.17 | 3.4 |
| #5 PlantFusion | Not named | 500 mg | Pomegranate 50 mg | Unnamed claim | $1.83 | 3.3 |
| #6 Pure O Elements | Not named | 500 mg | NAD, resveratrol, CoQ10 | Unnamed claim | $2.00 | 3.1 |
| #7 Revive | Not named | 500 mg | Rhodiola, CoQ10, apigenin, PQQ, BioPerine | Unnamed claim | $2.50 | 3.0 |
| #8 Pure Encapsulations Renual | Mitopure | 250 to 500 mg | Resveratrol, CoQ10 | None found | $5.27 | 2.8 |
Prices are Amazon prices on October 19, 2026 and change often. Cost per 500 mg is the bottle price divided by the milligrams of urolithin A it holds, times 500. For Codeage, whose Amazon price was about a third of its own list price, we scored the list price. NSF listings were confirmed on nsfsport.com and info.nsf.org.
How to choose, and what to check first
Decide whether the trial ingredient matters to you. Mitopure is the form the research used and the only one with an FDA GRAS notice; other urolithin A is the same molecule, but we found no trials that named a non-Mitopure source and no regulatory filing for it. If you buy a non-Mitopure product, insist on independent verification.
Check the verification, not the purity claim. "98% pure" or "99.4% purity" describes the raw material, not what ended up in your capsule. Look for an NSF listing you can search yourself at nsfsport.com or info.nsf.org, or a certificate of analysis that names the lab.
Know what you are buying. Products labeled as urolithin A "precursors", or pomegranate extract alone, do not contain urolithin A, and many people make little from them. Count the urolithin A milligrams, not the total of a blend.
- Limited human safety data. People have taken up to 2,000 mg once and up to 1,000 mg a day for four months, with side effects similar to placebo, but we found no longer-term data.
- Pregnancy and breastfeeding. We found no human safety data; the trials were in adults, mostly over 40, plus one small study in older teenage athletes.
- Medications. We found no drug-interaction studies. Ask your doctor or pharmacist before combining it with prescription medicines.
- Expectations. The measured effects are on lab markers and some strength and endurance tests, mostly in company-funded trials, and the largest trials missed their main outcomes.
- Cost over time. Effects in trials took weeks to months, so budget for at least four months if you want to judge it fairly.
Frequently asked questions
What is urolithin A?
Urolithin A is a compound gut bacteria make from ellagitannins, found in pomegranates, walnuts and berries. In cell and animal studies it promotes mitophagy, the recycling of damaged mitochondria. Supplements provide it directly, usually as Mitopure, a synthetic form made by the Swiss company Amazentis.
Does urolithin A work?
The evidence is early and mixed. The largest trials, in older adults, middle-aged adults and elite runners, missed their main outcomes, though some secondary tests such as hamstring strength and short-term endurance improved, and blood markers of mitochondrial activity and inflammation changed. Most trials were funded by Mitopure's maker, and the two fully independent trials missed their main outcomes.
How much urolithin A should you take?
Trials used 500 mg or, more often, 1,000 mg a day for up to four months. Most single-ingredient products provide 500 mg a day. Follow your product's label and ask your clinician what fits you.
Is Mitopure better than other urolithin A?
It is the same molecule, but Mitopure is the form used in nearly all published trials and the only urolithin A with an FDA GRAS notice. We found no trials that named another urolithin A source, and independent tests have found labeled products well off their claims, so independent verification matters more for them.
Can you get urolithin A from pomegranate?
Only if your gut bacteria can make it. In one sponsor-funded study, about 40 percent of adults converted pomegranate juice into meaningful amounts, and other studies find 5 to 25 percent make none at all. In that study, 500 mg of urolithin A gave more than six times the exposure of a glass of juice.
Is urolithin A safe?
In trials up to 1,000 mg a day for four months, side effects were similar to placebo, and rat studies found no adverse effects at very high doses. We found no human data in pregnancy and no drug-interaction studies.
Is urolithin A approved by the FDA?
No supplement is FDA approved. Mitopure's maker filed a GRAS notice for urolithin A in foods, and FDA replied in 2018 that it had no questions; that covers food use at set amounts, not health claims.
The bottom line
The best urolithin A supplement is one that contains the urolithin A on its label, verified by someone other than the seller, at a price you can sustain for months. Timeline's Mitopure Softgels do that best and use the trial ingredient, Codeage is the value pick with an NSF listing, and ProHealth shows a named lab's result. Keep expectations modest: the largest trials missed their main goals, most of the research was paid for by one company, and we found no trial showing fewer falls, infections or other health events.