Deficiency Guide

Phosphorus / Phosphate deficiency

Symptoms, at-risk groups, and clinical context for phosphorus / phosphate deficiency. Sourced from NIH Office of Dietary Supplements and StatPearls.

Phosphorus deficiency (hypophosphatemia) is rare and almost never caused by a low diet. It usually comes from medical conditions such as hyperparathyroidism, kidney tubule defects, diabetic ketoacidosis and refeeding after severe malnutrition.

Common symptoms

  • Loss of appetite
  • Anemia
  • Muscle weakness, especially near the hips and shoulders
  • Bone pain, and rickets in children or osteomalacia in adults
  • Higher risk of infection
  • Numbness or tingling
  • Loss of coordination
  • Confusion
  • In refeeding syndrome: breathing failure, heart failure, coma and death

At-risk groups

  • People with severe malnutrition who start being fed again (refeeding syndrome), including those with anorexia nervosa, excessive alcohol intake, very low body weight or chronic illnesses such as cancer
  • People recovering from diabetic ketoacidosis
  • People with hyperparathyroidism or kidney tubule defects
  • People taking aluminum hydroxide antacids for 3 months or longer
  • People with rare genetic phosphate disorders such as X-linked hypophosphatemic rickets
  • Very low birthweight preterm infants
When to see a doctorLow phosphate almost always points to an underlying medical condition, so see a doctor rather than self-supplementing. Anyone recovering from severe malnutrition, anorexia or prolonged fasting needs medically supervised refeeding, because refeeding syndrome can be life threatening.
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Related deficiencies

Nutrients with overlapping symptoms — useful when investigating an unclear clinical picture.